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Hypotrichosis simplex

7 OMIM references -
6 associated genes
12 signs/symptoms

PROTEIN INTERACTIONS: 2
COMMON SIGNS: 1

Fibronectin glomerulopathy

2 OMIM references -
1 associated gene
10 signs/symptoms

Hypotrichosis simplex

Fibronectin glomerulopathy

APCDD1	(UniProt - OMIM)		FN1	(UniProt - OMIM)
DSG4	(UniProt - OMIM)
LIPH	(UniProt - OMIM)
LPAR6	(UniProt - OMIM)
RPL21	(UniProt - OMIM)
SNRPE	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	RPL21 SNRPE	(0.72) (0.72)	FN1 FN1

Citations in the biomedical literature:

Hypotrichosis simplex		Fibronectin glomerulopathy
	Synonym(s): - Hereditary hypotrichosis simplex		Synonym(s): - GFND - Glomerulopathy with fibronectin deposits

	Classification (Orphanet): - Rare genetic disease - Rare skin disease		Classification (Orphanet): - Rare genetic disease - Rare renal disease

	Classification (ICD10): - Diseases of the skin and subcutaneous tissue -		Classification (ICD10): - Diseases of the genitourinary system -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: variable Average age of death: - Type of inheritance: autosomal dominant

	External references: 7 OMIM references - 1 MeSH reference: C537160		External references: 2 OMIM references - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance

Hypotrichosis simplex		Fibronectin glomerulopathy
	Very frequent - Absent / decreased lashes - Absent / decreased / thin eyebrows - Alopecia - Autosomal recessive inheritance - Decreased body hair / axillar / pubic hairlessness - Hypotrichosis / atrichia / atrichiasis / scalp hairlessness Frequent - Lanugo - Woolly / frizzy hair Occasional - Follicular / erythematous / edematous papules / milium - Hyperkeratosis / ainhum / hyperkeratotic skin fissures - Pruritus / itching		Very frequent - Chronic arterial hypertension - Edema of the legs / lower limbs - Functional anomalies of the kidney and the urinary tract - Hematuria / microhematuria - Nephrotic syndrome - Proteinuria - Renal failure - Renal glomerular defect / glomerulopathy Occasional - Intracranial / cerebral / meningeal hemorrhage